The risk of progression from MCI to AD: stages defined by cognition, function,
and behavior. 
   Lead Investigator:    Tzeyu Michaud
   Institution      :    University of Nebraska Medical Center
   E-Mail           :    tzeyu.michaud@unmc.edu
   Proposal ID      :    616



   Proposal Description:
   Researchers have advocated to define AD stages by three symptom                   domains-cognition, function and behavior- instead of the cognitive measurement    only.                                                                             Our study aims to estimate the transition probabilities from MCI to AD and        among AD stages defined by cognition, function, and behavior, and death while     controlling the demographic, BMI, family history, genotype, medication history,   and comorbidity covariates. The estimate transition probabilities by these        three domains could be further applied in the decision-analytic model for the     AD intervention modeling.